Chestnuts (not to be confused with horse chestnuts or water chestnuts, which are not related) have 4 allergenic proteins, Cas s 1, Cas s 5, Cas s 8 and Cas s 9.
Cas s 1 is a Bet v 1 allergen, so is associated with Pollen Food Allergy Syndrome.
Cas s 5 is a chitinase, this is a plant derived enzyme made by the plant to act as a defence against fungal attacks
Cas s 8 is a Lipid Transfer Protein (LTP). These are panallergens found in many plants.
Cas s 9 is a small heat shock protein. This is a unique allergen to chestnuts.
You may have Pollen Food Allergy Syndrome
if you suffer from chestnut allergy with oral allergy symptoms to 3 or more of the foods mentioned in cross reactivity section.
Chestnut allergy is most commonly seen in conjunction with allergies to other foods presenting as Latex Food Syndrome
. This is due to the high level of chitinase. Latex Food Syndrome is caused by the body confusing the proteins it encounters in food to that of latex proteins to which it is already sensitised.
LTP's are a group of proteins which can cause more serious allergic reactions in patients, you may suffer from LTP Syndrome
if you suffer IgE type allergy symptoms to foods mentioned in the cross reactivity section below.
If sensitised to birch tree pollen
you may have Pollen Food Allergy Syndrome and may also react to apple, pear, peach, plum, nectarine, apricots, cherries, chestnut, kiwi, tomato, celery, carrot, potato, parsnip, pepper, dill, cumin, peas, coriander, fennel, hazelnut, walnut, almonds, peanuts, lentils and beans.
Foods linked to Latex Food Syndrome may have linked allergies to foods which contain high levels of chitinase, like avocado, banana, corn (maize), kiwi, papaya, pomegranate and tomatoes.
Common foods involved in LTP allergy include kiwi, strawberries, sunflower seeds, walnut, apple, mulberry, banana, pea, apricot, cherry, plum, almond, peach pomegranate, raspberry, tomato, grape, celery, peanut, asparagus, cabbage, broccoli, chestnut, lemon, tangerine, orange, hazelnut, lettuce, lentils, lupin, green bean, pear, mustard, wheat and maize.
Allergen Encyclopedia - Chestnut
Science Direct - Lipid Transfer Proteins
Science Direct - Latex Allergy
Anaphylaxis Campaign - Sweet Chestnuts
Anaphylaxis Campaign - LTP Syndrome
Allergy information for: Chestnut (Castanea sativa)
Articles and Journals
Birch pollen allergy in Europe, 2018
Differential allergen sensitization patterns in chestnut allergy with or without associated latex-fruit syndrome, 2006
Chestnut as a Food Allergen: Identification of Major Allergens, 2005
Chestnut allergy - Beyond the latex-fruit syndrome, 2004
Lipid-transfer proteins as potential plant panallergens: cross-reactivity among proteins of Artemisia pollen, Castanea nut and Rosaceae fruits, with different IgE-binding capacities, 2000
Class I chitinases as potential panallergens involved in the latex-fruit syndrome, 1999
Latex allergy: clinical features and cross-reactivity with fruits, 1994
Purification, characterization and N-terminal amino acid sequence of a new major allergen from European chestnut pollen--Cas s 1, 1993
Let me know if you found any of these interesting or useful.
If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.