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COMPREHENSIVE ALLERGY RESOURCES FOR EVERYONE - THE TOP 14 ALLERGENS AND BEYOND

COMPREHENSIVE ALLERGY RESOURCES FOR EVERYONE - THE TOP 14 ALLERGENS AND BEYOND
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HAZELNUT ALLERGY


Key Allergens

There are 8 allergens associated with an allergy to hazelnuts. There are 3 additional allergens that are associated with hazel pollen.

Cor a 1 is an airway allergen and is a Bet v 1 protein. These proteins are associated with pollen, but can sometimes give oral allergy symptoms after eating certain nuts, fruits or vegetables.

Cor a 2 is a profilin protein, these are panallergens which can cause allergic reactions across multiple foods.

Cor a 8 is a lipid transfer protein (LTP). This group of proteins commonly cause allergic symptoms.

Cor a 9 is an 11S protein (also known as legumin like). Cor a 11 is a 7S protein (also known as vicilin like) and Cor a 14 is a 2S protein. These groups of proteins are involved in seed storage and are commonly found in many nuts, legumes and seeds. This is why a person suffering from a tree nut allergy is often allergic to whole groups of nuts, legumes and seeds.

Cor a 12, 13 and 14 are all oleosin proteins, these are proteins mostly associated with nuts and seeds. The proteins are involved in preventing the build up of oil molecules and may have role in lipid store degredation during plant germination.


Associated Syndromes

Hazelnut allergy is often linked to LTP Syndrome, where similarly shaped proteins in other plants resemble those in hazelnuts and elicit an allergic reaction.

The Bet v 1 proteins are associated with Pollen Food Allergy Syndrome. If you are allergic to 3 or more foods in the cross reactivity section with oral allergy type syndromes then you may have pollen food allergy syndrome.

Allergy to peanut is sometimes linked to Celery-Mugwort-Spice Syndrome as the sensitising allergen is a profilin protein called Art v 4, these proteins are also sometimes also called Bet v 2 proteins.

There is a link between peanuts and Latex Food Syndrome. The plant involved in latex allergy Hevea brasiliensis, the rubber tree plant, has an allergen called Hev b 8 which is a profilin protein. Those very sensitised to latex may have a contact allergic reaction from other foods or plants containing profilin proteins, there is less evidence of this than sensitisation to other latex linked proteins like hevein and chitinases.


Cross Reactivity

Common foods involved in LTP allergy include kiwi, strawberries, sunflower seeds, walnut, apple, mulberry, banana, pea, apricot, cherry, plum, almond, peach pomegranate, raspberry, tomato, grape, celery, peanut, asparagus, cabbage, broccoli, chestnut, lemon, tangerine, orange, hazelnut, lettuce, lentils, lupin, green bean, pear, mustard, wheat and maize.

If sensitised to birch pollen you may have Pollen Food Allergy Syndrome and may also react to kiwi, pear, peach, plum, nectarine, apricots, cherries, tomato, celery, crrot, potato, parsnip, pepper, dill, cumin, peas, coriander, fennel, mung beans, walnut, almonds, peanuts, lentils and apples.

Hazelnut is broadly linked to other fruit profilin allergies. Allergy to celery, peanut, soyabeans, walnut, lupin, almonds, mustard, lychee, kiwi, pineapple, chilli, melon, orange, strawberry, apple, banana, aubergine (eggplant), peach, pear, tomato, dates, cherry, carrot, barley and wheat. Allergic reactions to some of these foods may be considered a marker of profilin hypersensitivity.

Other food containing 2S albumin seed storage proteins are cashews, peanuts, almonds, mustard seed, rapeseed, turnip, chickpeas, brazil nuts, pistachio, buckwheat, soya beans, sunflower seeds, walnuts, kiwi, castor beans and sesame seeds.

There is a lot of cross reactivity between 2S and 11S seed storage proteins, the only other food containing 11S proteins not mentioned above is pumpkin.

Other foods containing 7S seed storage proteins not mentioned in the list above are lupin, lentils, macadamia, peas and mung bean.

Oleosin proteins are also found in buckwheat, sesame and peanuts.


Resources

Websites

Allergen Encylcopedia - Hazelnut

Science Direct - Oleosin

What Are the Symptoms of a Nut Allergy?

Allergy UK - Quick Guide to Tree Nut Allergy

FARE - Tree Nut Allergy

Anaphylaxis Campaign - Peanut and Tree nut allergies

Allergy information for: Hazelnut (Corylus avellana)

Anaphylaxis Campaign - Hazelnuts


Articles and Journals

Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic children, 2021

Hazelnut Allergy, 2021

For hazelnut allergy, component testing of Cor a 9 and Cor a 14 is relevant also in birch-endemic areas, 2020

Oral Immunotherapy for Hazelnut Allergy: A Single-Center Retrospective Study on 100 Patients, 2019

Current perspectives on tree nut allergy: a review, 2018

Tree nut allergens, 2018

Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey, 2015

Isolation, cloning, and characterization of the 2S albumin: a new allergen from hazelnut, 2010

Lipid transfer protein–linked hazelnut allergy in children from a non-Mediterranean birch-endemic area, 2008

Hazelnut allergy: from pollen-associated mild allergy to severe anaphylactic reactions, 2008

2S Albumin Storage Proteins: What Makes them Food Allergens?, 2008

Hazelnut (Corylus avellana) vicilin Cor a 11: molecular characterization of a glycoprotein and its allergenic activity, 2004

Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results, 2002

Identification of an 11S globulin as a major hazelnut food allergen in hazelnut-induced systemic reactions, 2002



Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.


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