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COMPREHENSIVE ALLERGY RESOURCES FOR EVERYONE - THE TOP 14 ALLERGENS AND BEYOND

COMPREHENSIVE ALLERGY RESOURCES FOR EVERYONE - THE TOP 14 ALLERGENS AND BEYOND
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MACADAMIA NUT ALLERGY


Key Allergens

There are two key food allergens found in macadamia nuts, Mac i 1 and Mac i 2.

Mac i 1 is a vicilin like protein used in storage in the plant. This is also sometimes described as a 7S seed storage protein.

Mac i 2 is a legumin like protein, this is similar to the protein casein in milk. This is also often described as an 11S seed storage protein.

Seed storage proteins are found in multiple types of nuts, seeds and legumes which can lead to cross reactivity.


Associated Syndromes

Macadamia nut allergy is not currently linked to any allergic syndromes.

Cross Reactivity

Other foods containing vicilin like proteins are cashew, coconut, pecan, hazelnuts, buckwheat, soyabean, walnut, lentil, lupin, peas, peanuts, pistachio, sesame and mung bean.

There is a lot of crossover between foods containing vicilin and those containing legumin proteins. Foods containing legumin but not vicilin proteins are almonds, brazil nuts, kiwi, pumpkin and mustard.


Resources

Websites

Science Direct - Macadamia Nuts

Allergen Encyclopedia - Macadamia Nuts

What Are the Symptoms of a Nut Allergy?

Allergy UK - Quick Guide to Tree Nut Allergy

FARE - Tree Nut Allergy

AAAAI - Tree Nut Allergy

Anaphylaxis Campaign - Peanut and Tree nut allergies

Can You Be Allergic to Just One Type of Tree Nut?


Articles and Journals

Identification of vicilin, legumin and antimicrobial peptide 2a as macadamia nut allergens, 2021

Macadamia nut allergy in children: Clinical features and cross-reactivity with walnut and hazelnut, 2021

IgE-binding to vicilin-like antimicrobial peptides is associated with systemic reactions to macadamia nut, 2020

Defining challenge-proven coexistent nut and sesame seed allergy: A prospective multicenter European study, 2020

Clinical features and allergen analysis in five children with macadamia nut allergy, 2018

Tree nut allergens, 2018

Current perspectives on tree nut allergy: a review, 2018

Allergy to macadamia nut, 2007



Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.


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