Carica papaya is a plant from the order Brassicales which produces fruit called papaya.

There are 2 allergens in papaya fruit recognised by the World Health Organization, Cari p 1 is a polygalacturonase (PG) and is responsible in part for ripening of fruit. This protein is usually a pollen allergen found in cedar and cypress trees. In food allergy PGs are responsible for oral allergy type symptoms as the patient first becomes sensitised to the pollen of this plant and then to the fruit.

A second allergen, Cari p 2, was identified in early 2020, it is a cysteine protease protein and is most likely the cause of the link to latex allergies.

You may have Pollen-Food Allergy Syndrome if you suffer from allergic reactions to both the pollen and fruit of the papaya plant.

Latex Food Syndrome is caused by the body confusing the proteins it encounters in food to that of latex proteins to which it is already sensitised.

No other foods contain polygalacturonase, but it is found in the pollen of cedar, plane, cypress and olive trees as well as Timothy grass.

Other foods containing cysteine protease are kiwi, papaya and potatoes. These proteins also airway allergens and are found in dust mites and ragweed pollen.

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