Carica papaya is a plant from the order Brassicales which produces fruit called papaya.
There are 2 allergens in papaya fruit recognised by the World Health Organization, Cari p 1 is a polygalacturonase (PG) and is responsible in part for ripening of fruit. This protein is usually a pollen allergen found in cedar and cypress trees. In food allergy PGs are responsible for oral allergy type symptoms as the patient first becomes sensitised to the pollen of this plant and then to the fruit.
A second allergen, Cari p 2, was identified in early 2020, it is a cysteine protease protein and is most likely the cause of the link to latex allergies.
You may have Pollen-Food Allergy Syndrome
if you suffer from allergic reactions to both the pollen and fruit of the papaya plant.
Latex Food Syndrome
is caused by the body confusing the proteins it encounters in food to that of latex proteins to which it is already sensitised.
No other foods contain polygalacturonase, but it is found in the pollen of cedar, plane, cypress and olive trees as well as Timothy grass.
Other foods containing cysteine protease are kiwi, papaya and potatoes. These proteins also airway allergens and are found in dust mites and ragweed pollen.
Allergen Encyclopedia - Papaya
DermNet NZ - Latex Allergy
Food Allergy to Papaya
Articles and Journals
Molecular Characterization of Chymopapain: A Major Allergen Associated with Papaya Allergy, 2020
Cari p 1, a Novel Polygalacturonase Allergen From Papaya Acting as Respiratory and Food Sensitizer, 2018
Latex-Papaya Syndrome: An association infrequent but of great relevance, 2017
Food allergy - "papaya: pear or pain", 2010
Class I chitinases as potential panallergens involved in the latex-fruit syndrome, 1999
Carica papaya pollen allergy, 1998
Latex allergy: clinical features and cross-reactivity with fruits, 1994
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