ALLERGY RESOURCES

COMPREHENSIVE ALLERGY RESOURCES FOR EVERYONE - THE TOP 14 ALLERGENS AND BEYOND

COMPREHENSIVE ALLERGY RESOURCES FOR EVERYONE - THE TOP 14 ALLERGENS AND BEYOND

PAPAYA ALLERGY


Key Allergens

Carica papaya is a plant from the order Brassicales which produces fruit called papaya.

There are 2 allergens in papaya fruit recognised by the World Health Organization, Cari p 1 is a polygalacturonase (PG) and is responsible in part for ripening of fruit. This protein is usually a pollen allergen found in cedar and cypress trees. In food allergy PGs are responsible for oral allergy type symptoms as the patient first becomes sensitised to the pollen of this plant and then to the fruit.

A second allergen, Cari p 2, was identified in early 2020, it is a cysteine protease protein and is most likely the cause of the link to latex allergies.

Associated Syndromes

You may have Pollen-Food Allergy Syndrome if you suffer from allergic reactions to both the pollen and fruit of the papaya plant.

Latex Food Syndrome is caused by the body confusing the proteins it encounters in food to that of latex proteins to which it is already sensitised.

Cross Reactivity

No other foods contain polygalacturonase, but it is found in the pollen of cedar, plane, cypress and olive trees as well as Timothy grass.

Other foods containing cysteine protease are kiwi, papaya and potatoes. These proteins also airway allergens and are found in dust mites and ragweed pollen.

Resources

Websites

Allergen Encyclopedia - Papaya

DermNet NZ - Latex Allergy

Food Allergy to Papaya


Articles and Journals

Molecular Characterization of Chymopapain: A Major Allergen Associated with Papaya Allergy, 2020

Cari p 1, a Novel Polygalacturonase Allergen From Papaya Acting as Respiratory and Food Sensitizer, 2018

Latex-Papaya Syndrome: An association infrequent but of great relevance, 2017

Food allergy - "papaya: pear or pain", 2010

Class I chitinases as potential panallergens involved in the latex-fruit syndrome, 1999

Carica papaya pollen allergy, 1998

Latex allergy: clinical features and cross-reactivity with fruits, 1994



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