Key Allergens

The allergens associated with a pear allergy are called Pyr c 1, Pyr c 3, Pyr c 4 and Pyr c 5.

Most people suffering from this allergy are thought to be sensitised to the protein Pyr c 1, which is similar in shape to Bet v 1 which is a protein found in birch pollen. This can cause cross reactions with other fruit.

Pyr c 3 is a lipid transfer protein (LTP), more severe reactions to eating pears are thought to be caused by these proteins.

Pyr c 4 is a profilin protein, these proteins are considered to be panallergens and can cause issues over many groups of foods.

Pyr c 5 is an isoflavone reductase related protein.

Associated Syndromes

You may have Pollen-Food Allergy Syndrome if you suffer from cherry allergy with oral allergy symptoms to 3 or more of the foods mentioned in cross reactivity section.

Allergy to pear is sometimes linked to Celery-Mugwort-Spice Syndrome as the sensitising allergen is a profilin protein called Art v 4, these proteins are also sometimes also called Bet v 2 proteins.

There is a link between pear and Latex Food Syndrome. The plant involved in latex allergy Hevea brasiliensis, the rubber tree plant, has an allergen called Hev b 8 which is a profilin protein. Those very sensitised to latex may have a contact allergic reaction from other foods or plants containing profilin proteins, there is less evidence of this than sensitisation to other latex linked proteins like hevein and chitinases.

You may be suffering from LTP Syndrome if you suffer allergic reactions from eating 3 or more foods mentioned in the cross reactivity section below.

Cross Reactivity

If sensitised to alder tree pollen you may have Pollen Food Allergy Syndrome and may also react to apple, peach, pear, parsley, celery, almonds and hazelnuts.

If sensitised to birch tree pollen you may have Pollen Food Allergy Syndrome and may also react to kiwi, pear, peach, plum, nectarine, apricots, apple, tomato, celery, carrot, potato, parsnip, pepper, dill, cumin, peas, coriander, fennel, hazelnut, walnut, almonds, peanuts, lentils and beans.

Common foods involved in LTP allergy include kiwi, strawberries, sunflower seeds, walnut, apple, mulberry, banana, pea, apricot, cherry, plum, almond, peach pomegranate, raspberry, tomato, grape, celery, peanut, asparagus, cabbage, broccoli, chestnut, lemon, tangerine, orange, hazelnut, lettuce, lentils, lupin, green bean, pear, mustard, wheat and maize.

Other foods containing plant profilins are carrot, kiwi, pineapple, celery, peanut, chilli, watermelon, orange, hazelnut, melon, strawberry, soya, barley, walnut, lychee, lupin, apple, banana, date, cherry, almond, peach, pear, mustard, tomato, aubergine and wheat.

Only carrots and pears contain isoflavone reductase-like proteins.



Allergen Encyclopedia - Pear

DermNet NZ - Pollen Food Allergy Syndrome

British Dietetic Association - PFAS vs LTP Syndrome

OAS – When Raw Fruit is Forbidden

Allergy information for: Pear (Pyrus communis )

Allergy to Fruit - Anaphylaxis Campaign

Allergy UK - Oral Allergy Syndrome

Patient UK - Oral Allergy Syndrome

Articles and Journals

Birch Pollen Related Pear Allergy: A Single-Blind Oral Challenge trial with 2 Pear Cultivars, 2021

The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area, 2021

Pollen-food allergy syndrome and component sensitization in adolescents: A Japanese population-based study, 2021

Pollen-related food allergy in children with seasonal allergic rhinitis, 2021

Pollen-food allergy syndrome in children, 2020

Pru p 3 oral immunotherapy efcacy, induced immunological changes and quality of life improvement in patients with LTP syndrome, 2020

Pyr c 1, the major allergen from pear (Pyrus communis), is a new member of the Bet v 1 allergen family, 2001

Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.

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