The key allergens in pineapple are Ana c 1 and Ana c 2.
Ana c 1 is a profilin
protein, this is a panallergen known to sometimes cause allergy reactions in multiple foods containing similar proteins.
Ana c 2 is called bromelain. This has been known to cause IgE mediated allergies and symptoms most often related to the respiratory system. This biochemical is commonly extracted from pineapple and used in cosmetics and food production where it is frequently used as a meat tenderiser (which is why your lips may tingle when eating pineapple).
Bromelain is a papain, which is the active constituent in latex-related fruits, this is the protein which can cause cross reactivity with latex.
If you suffer from pineapple allergy and other foods mentioned in the cross reactivity section below you may suffer from Latex Food Syndrome.
Allergy to pineapple is sometimes linked to Celery-Mugwort-Spice Syndrome
as the sensitising allergen is a profilin protein called Art v 4, these proteins are also sometimes also called Bet v 2 proteins.
If sensitised to pineapple you may also be allergic to banana, papaya, avocado, chestnut, corn, kiwi, pomegranate and latex.
Other foods containing plant profilin proteins include pineapple, kiwi, celery, peanut, chilli, watermelon, muskmelon, hazelnut, orange, carrot, strawberry, soya beans, barley, walnut, lychee, lupin, apple, banana, dates, cherry, almond, peach, pear, mustard, tomato, aubergine and wheat.
Allergen Encyclopedia - Pineapple
Science Direct - Papain
Allergy information for: Pineapple (Ananas comosus )
Articles and Journals
The many flavors of pineapple reactions, 2019
Misleading Allergens in the Diagnosis of Latex Allergy: Profilin and Cross-Reactive Carbohydrate Determinants, 2018
Prevalence of oral allergy syndrome in children with allergic diseases, 2017
IgE reactivity to profilin in pollen-sensitized subjects with adverse reactions to banana and pineapple, 2002
Allergy to latex and papain, 1995
Systemic allergic reaction and diarrhoea after pineapple ingestion, 1993
Asthma caused by bromelain: an occupational allergy, 1988
Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure, 1979
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