ALLERGY RESOURCES

COMPREHENSIVE ALLERGY RESOURCES FOR EVERYONE - THE TOP 14 ALLERGENS AND BEYOND

COMPREHENSIVE ALLERGY RESOURCES FOR EVERYONE - THE TOP 14 ALLERGENS AND BEYOND
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PUMPKIN ALLERGY


Key Allergens

There are 2 allergenic proteins found in pumpkins, Cuc ma 4 and Cuc ma 5. The first is an 11S seed storage protein and the second is a 2S seed storage protein.

Associated Syndromes

Pumpkins are not currently associated with any allergic syndromes, but are sometimes linked to carotenoderma, which is a skin condition causing orange skin pigmentation. This is due to overeating foods high in beta carotene like pumpkins, carrots, sweet potato and mango.

Cross Reactivity

Other food containing 2S albumin seed storage proteins are cashews, peanuts, mustard seed, rapeseed, turnip, chickpeas, hazelnuts, pistachio, buckwheat, soya beans, sunflower seeds, brazil nuts, walnuts, kiwi, castor beans and sesame seeds.

There is a lot of cross reactivity between 2S and 11S seed storage proteins, foods containing 11S seed storage proteins are almonds and macadamia nuts.


Resources

Websites

Science Direct - Pumpkins

Allergen Encyclopedia - Pumpkin

DermNet NZ - Carotenoderma

Allergy information for: Pumpkin (Cucurbita maxima)

Anaphylaxis Campaign - Allergy to Vegetables


Articles and Journals

Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study, 2021

2S albumins and 11S globulins, two storage proteins involved in pumpkin seeds allergy, 2020

Anaphylaxis Secondary to Ingestion of Pumpkin Seeds in a Child: A Case Report, 2019

Allergy to Pumpkin Seeds, 2017

Hypersensitivities to sesame and other common edible seeds, 2016

2S Albumin Storage Proteins: What Makes them Food Allergens?, 2008

Allergy to pumpkin and cross-reactivity to other Cucurbitaceae fruits, 2000

Food allergy to pumpkinseed--characterization of allergens, 1997



Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.


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