Pumpkins are not currently associated with any allergic syndromes, but are sometimes linked to carotenoderma, which is a skin condition causing orange skin pigmentation. This is due to overeating foods high in beta carotene like pumpkins, carrots, sweet potato and mango.
Other food containing 2S albumin seed storage proteins are cashews, peanuts, mustard seed, rapeseed, turnip, chickpeas, hazelnuts, pistachio, buckwheat, soya beans, sunflower seeds, brazil nuts, walnuts, kiwi, castor beans and sesame seeds.
There is a lot of cross reactivity between 2S and 11S seed storage proteins, foods containing 11S seed storage proteins are almonds and macadamia nuts.
Science Direct - Pumpkins
Allergen Encyclopedia - Pumpkin
DermNet NZ - Carotenoderma
Allergy information for: Pumpkin (Cucurbita maxima)
Anaphylaxis Campaign - Allergy to Vegetables
Articles and Journals
Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study, 2021
2S albumins and 11S globulins, two storage proteins involved in pumpkin seeds allergy, 2020
Anaphylaxis Secondary to Ingestion of Pumpkin Seeds in a Child: A Case Report, 2019
Allergy to Pumpkin Seeds, 2017
Hypersensitivities to sesame and other common edible seeds, 2016
2S Albumin Storage Proteins: What Makes them Food Allergens?, 2008
Allergy to pumpkin and cross-reactivity to other Cucurbitaceae fruits, 2000
Food allergy to pumpkinseed--characterization of allergens, 1997
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