Sesame seeds are from a plant in the Pedaliaceae
family of plants. Other plants in this family are flowers.
There are seven allergens associated with sesame allergy.
2 are 2S seed storage proteins
, 1 is a 7S seed storage protein
and 2 are 11S seed storage proteins
. Seed storage proteins are generally linked to tree nut, peanut and seed allergies.
The last two allergens are oleosin proteins
, which are found in parts of plants with a high oil content.
Many allergenic proteins are broken down with heat and processing, this is not the case with seed storage proteins or oleosins, so sesame oil which is made from ground and processed sesame seeds still has the potential to cause allergic reactions.
Sesame seeds and peanuts contain many of the same allergenic proteins, so cross reactivity is a possibility.
Sesame is a low FODMAP food. FODMAP stands for F
olyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.
Sesame seeds are low in salicylates, these have the potential to cause gastrointestinal food intolerance symptoms in people who are sensitive to salicylates.
Although it is a seed and these are usually considered to contain lectins, sesame is actually low in them. Lectins are another cause of food intolerance.
Sesame allergy is not currently linked to any allergic syndromes.
Other food containing 2S albumin seed storage proteins are cashews, peanuts, almonds, mustard seed, rapeseed, turnip, chickpeas, hazelnuts, pistachio, buckwheat, soya beans, sunflower seeds, brazil nuts, kiwi, castor beans and walnuts.
There is a lot of cross reactivity between 2S and 11S seed storage proteins, the only other food containing 11S proteins not mentioned above is pumpkin.
Other foods containing vicilin-like (7S seed storage) proteins not mentioned in the list above are lupin, lentils, macadamia nuts, peas and mung bean.
Oleosin proteins are also found in peanuts, quinoa, palm oil, buckwheat and hazelnuts and are already mentioned as cross reacting with other proteins found in sesame.
Science Direct - Sesame
Allergen Encyclopedia - Sesame Seeds
Anaphylaxis Campaign - Sesame Allergy
FARE - Sesame Allergy
Allergy information for: Sesame (Sesamum indicum)
Healthline - FODMAP Foods
ATP Science - Salicylate Food List
Articles and Journals
Clinical experience with sesame oral immunotherapy and a quality-of-life assessment, 2022
Adverse Events and Labeling Issues Related to Suspected Sesame Allergy Reported in an Online Survey, 2021
Recurrent acute pancreatitis secondary to sesame allergy, 2021
Prevalence and Diagnosis of Sesame Allergy in Children with IgE-Mediated Food Allergy, 2020
Prevalence and Severity of Sesame Allergy in the United States, 2019
Sesame allergy: current perspectives, 2017
Hypersensitivities to sesame and other common edible seeds, 2016
A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada, 2010
Identification of 2 new sesame seed allergens: Ses i 6 and Ses i 7, 2007
Identification of oleosins as major allergens in sesame seed allergic patients, 2006
Identification of sesame seed allergens by 2-dimensional proteomics and Edman sequencing: seed storage proteins as common food allergens, 2002
The major allergen of sesame seeds (Sesamum indicum) is a 2S albumin, 2001
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