Tangerine oranges are also sometimes known as mandarins. The allergen associated with tangerine allergy is called Cit r 3.
Cit r 3 is a Lipid Transfer Protein (LTP)
, these proteins are resistant to heat and are found in many types of plants. Patients suffering from a more severe allergy to cooked fruit may be sensitised to this group of proteins.
There is a case study (link at the bottom) of anaphylaxis due to the consumption of tangerine seeds - most likely a cross reaction from a nut allergy (as there are commonly seed storage proteins
in the seeds of fruits). This is a very rare occurrence tangerines and oranges are not usually considered to be cross reactive with tree nuts. You can read more about anaphylactic reactions to fruit HERE
You may be suffering from LTP Syndrome
if you have reactions to various fruits, vegetables and nuts and your reactions continue to be severe after you have discarded the peel and have cooked the food.
You may have allergic contact dermatitis if you have skin problems after coming into contact with tangerine essential oils or are sensitive to the chemicals in the peel.
Common foods involved in LTP allergy include kiwi, strawberries, sunflower seeds, walnut, apple, mulberry, banana, pea, apricot, cherry, plum, almond, peach pomegranate, raspberry, tomato, grape, celery, peanut, asparagus, cabbage, broccoli, chestnut, lemon, tangerine, orange, hazelnut, lettuce, lentils, lupin, green bean, pear, mustard, wheat and maize.
Orange allergens have shown cross-reactivity with the major peach allergen Pru p 3.
Allergen Encyclopedia - Oranges
DermNet NZ - Contact Dermatitis to Essential Oils
Lipid Transfer Proteins (LTP Syndrome)
Allergy to Fruit - Anaphylaxis Campaign
Do You Have a Citrus Allergy? Learn the Symptoms
What You Need to Know About Allergic Reaction to Essential Oils
Articles and Journals
Lemon seed allergy: a case presentation, 2020
Co-sensitization to the fruit seeds and raw potato in children with cashew nut allergy, 2020
Lipid Transfer Protein allergy in the United Kingdom: Characterization and comparison with a matched Italian cohort, 2019
Citrus Allergy from Pollen to Clinical Symptoms, 2013
Anaphylaxis caused by tangerine seeds, but no tangerine fruit, 2008
Anaphylaxis to lemon soap: citrus seed and peanut allergen cross-reactivity, 2007
Anaphylaxis from Mandarin (Citrus reticulata): Identification of Potential Responsible Allergens, 2007
Lipid transfer proteins and allergy to oranges, 2005
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