There are three allergens associated with cashew allergy.
Ana o 1 is a vicilin like protein, also called a 7S seed storage globulin protein
. 7S globulin proteins are involved in the hydration processes of plant cells and are important for breakdown during germination.
Ana o 2 is a legumin like protein, also known as a 11S seed storage globulin protein
. 11S globulin proteins are involved in storage of nutrients in the plant.
Ana o 3 is a 2S albumin protein
which are found in most nuts and some seeds and cause people to be allergic to whole groups of tree nuts.
Cashews are strongly linked to peanut allergies as they both contain all 3 types of seed storage proteins, giving a lot of potential for cross reactivity.
Cashew Nut allergy is not currently associated with any allergic syndromes.
Other food containing 2S albumin seed storage proteins are brazil nuts, peanuts, almonds, mustard seed, rapeseed, turnip, chickpeas, hazelnuts, pistachio, buckwheat, soya beans, sunflower seeds, walnuts, kiwi, castor beans and sesame seeds.
Other foods containing 7S seed storage proteins not mentioned above are coconut, lentil, lupin, macadamia nuts and peas.
Almonds contain 11S seed storage proteins and are not included in either of the above lists. Visit the 11S seed storage globulin protein
page for the extensive list.
Allergen Encyclopedia - Cashew Nut
DermNet NZ - Cashew Nuts
What Are the Symptoms of a Nut Allergy?
Allergy UK - Quick Guide to Tree Nut Allergy
FARE - Tree Nut Allergy
AAAAI - Tree Nut Allergy
Anaphylaxis Campaign - Peanut and Tree nut allergies
Can You Be Allergic to Just One Type of Tree Nut?
Anaphylaxis Campaign - Cashew Nuts
Allergy information for: Cashew (Anacardium occidentale)
Articles and Journals
Optimizing tools for evaluating challenge outcome in children with cashew nut allergy, 2021
Ana o 3 sIgE testing increases the accuracy of cashew allergy diagnosis using a two-step model, 2021
No cashew allergy in infants introduced to cashew by age 1 year, 2021
Pistachio and cashew nut allergy in childhood: Predictive factors towards development of a decision tree, 2021
Food allergy endotype with high risk of severe anaphylaxis in children—Monosensitization to cashew 2S albumin Ana o 3, 2019
Tree nut allergens, 2018
Current perspectives on tree nut allergy: a review, 2018
Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children, 2017
2S Albumin Storage Proteins: What Makes them Food Allergens?, 2008
Cashew nut causes more severe reactions than peanut: case‐matched comparison in 141 children, 2007
Ana o 3, an important cashew nut (Anacardium occidentale L.) allergen of the 2S albumin family, 2005
A voluntary registry for peanut and tree nut allergy: characteristics of the first 5149 registrants, 2001
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