Key Allergens

Cacao is in the Malvaceae family of plants which includes okra, cotton and durian fruits. Cocoa beans are the seeds of this tree which are used to make chocolate and cacao.

Cocoa is a food that is not considered by the World Health Organisation (WHO) to contain any allergenic proteins, however there have been cases of cocoa allergies reported.

Most of the studies relating to cocoa allergy are from factory workers and chocolatiers who spend all of their time working with the product.

There is a 2S seed storage protein in cocoa which is similar to those proteins found in tree nuts. Cocoa is a highly processed product which is why is not thought to be particularly cross reactive with other foods containing 2S seed storage proteins.

Chocolate contains theobromine and caffeine which may cause people to believe they are allergic to cocoa instead of reacting to the caffeine.

Cocoa butter is the fat from cocoa beans and is used to make white chocolate and cosmetics. There is less evidence that this is the component of chocolate which people are allergic to.

Food Intolerances

Food is low in FODMAP Food is low in salicylates Food is medium in lectins

Chocolate often contains a lot of cows milk, so is not suitable, especially when eaten in large quantities, for people who are lactose intolerant. There are many dairy free alternative chocolates which are suitable for those with lactose intolerance.

Cocoa is a low FODMAP food. FODMAP stands for Fermentable oligosaccharides, disaccharides, monosaccharides and polyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.

Cocoa is a food low in salicylates. Salicylates have the potential to cause gastrointestinal food intolerance symptoms in people who are sensitive to salicylates.

Cacao plants are one of the few plants to contain a moderate amount of lectins, another cause of food intolerance. Cooking foods with lectins makes them more digestible and can reduce the symptoms of food intolerance.

You can read more about Food Intolerances on the dedicated Food Intolerance Page.

Associated Syndromes

Cocoa allergy or intolerance has not been linked to any allergenic syndromes.

Cross Reactivity

Other foods containing 2S seed storage proteins are peanuts, cashews, brazil nut, mustard, pecan, hazelnut, soya beans, walnut, pistachio, sesame and almonds.

Fruits and vegetables containing these proteins are kiwi, turnip, pumpkin and sichuan pepper.

2S seed storage proteins are also found in rapeseed, buckwheat, flaxseed, castor beans, mung bean, chickpea, sunflower seeds and pine nuts.

These food lists are not exhaustive, the most up to date food lists are on the Cross Reactivity Tools.



Science Direct - Theobroma cacao

Allergen Encyclopedia - Cacao

Allergy information for: Cocoa (Theobroma cacao)

Do I Have a Chocolate Allergy?

NY Allergy & Sinus Centers - Chocolate Allergy

FODMAPedia - Cocoa

ATP Science - Salicylate Foods

Articles and Journals

Allergy to Theobroma cacao

Botanical Impurities in the Supply Chain: A New Allergenic Risk Exacerbated by Geopolitical Challenges, 2024

Pattern of Food Allergen Sensitivity Amongst Adult Allergic Rhinitis Patients: A Four Year Central Indian Study, 2023

Allergy Safety Events in Health Care: Development and Application of a Classification Schema Based on Retrospective Review, 2022

Nutritional management of immediate hypersensitivity to legumes in vegetarians, 2022

Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic children, 2021

An exploratory public health investigation of the correlation between food allergies and pediatric obesity, 2021

Contribution to the estimation of the prevalence of food allergy in schoolchildren in the city of Guelma (Algeria), 2021

Not so sweet: True chocolate and cocoa allergy, 2019

Cocoa Diet and Antibody Immune Response in Preclinical Studies, 2017

The effects of cocoa on the immune system, 2013

Respiratory function and immunological status in cocoa and flour processing workers, 1998

Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.

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