Key Allergens

Rice is harvested from plants in the Poaceae family of plants. Other plants in this family include barley, corn, wheat, durum wheat and oats.

The allergens in rice are called Ory s 1 and Ory s 12. They are both considered to be airway allergens.

Ory s 1 is a beta expansin protein. These are found in the cell walls of plants and are a common cause of grass pollen allergies.

Ory s 12 is a profilin protein, most commonly causing allergic reactions in the airway, like hayfever.

Food Protein Induced Enterocolitis Syndrome (commonly known as FPIES) is often triggered by rice. After milk and soya milk, rice is one of the most common foods which triggers FPIES in children.

Food Intolerances

Food is low in FODMAP Food is medium in lectins

Rice is a low FODMAP food. FODMAP stands for Fermentable oligosaccharides, disaccharides, monosaccharides and polyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.

Rice contains lectins, with higher amounts in brown rice or wild rice over more processed white rices. Lectins can cause food intolerance symptoms in some people. The amount of lectin protein in food can be reduced by cooking for longer or soaking grains in water and rinsing before cooking. This breaks down the proteins and reduces reactions.

You can read more about Food Intolerances on the dedicated Food Intolerance Page.

Associated Syndromes

Allergic reactions to rice are commonly linked to Food Protein Induced Enterocolitis Syndrome (FPIES). This is a non IgE allergic condition in babies and young children which causes vomiting, diarrhoea and dehydration.

Cross Reactivity

Only barley contains beta expansin proteins as food allergens. As an airway allergen, multiple species of grasses, rye and maize all contain beta expansin.

Profilin proteins are both food and airway allergens. Other profilin airway allergens are ragweed, wormwood, grasses, birch trees, sunflower, olive, plantain, poplar, oak and maize.

Note these food lists are not exhaustive, you can find the most up to date information on the Cross Reactivity Tool.

Read more about Grain Allergens and Pseudocereals.



Allergen Encyclopedia - Rice

NY Allergy & Sinus Centers - Rice Allergy

Allergy information for: Rice (Oryza sativa )


Healthline - FODMAP Foods

Articles and Journals

Current and future perspectives on the consensus guideline for food protein-induced enterocolitis syndrome (FPIES), 2024

Food Protein Induced Enterocolitis Syndrome: A Culprit Food Analysis, 2023

Food Protein-induced Enterocolitis Syndrome Due to Rice in a Japanese Infant: A Case Report, 2022

Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology, 2021

An exploration of factors associated with food protein-induced enterocolitis syndrome: Birth, infant feeding and food triggers, 2021

Allergenic potential of rice-pollen proteins: expression, immuno-cross reactivity and IgE-binding, 2013

Food protein induced enterocolitis syndrome caused by rice beverage, 2013

A case of rice allergy in a patient with baker’s asthma, 2012

Rice-Induced Anaphylaxis: IgE-Mediated Allergy against a 56-kDa Glycoprotein, 2012

Bronchial asthma induced by rice, 1998

Cloning, expression and immunological characterization of Ory s 1, the major allergen of rice pollen, 1995

Immediate hypersensitive reactions to buckwheat ingestion and cross allergenicity between buckwheat and rice antigens in subjects with high levels of IgE antibodies to buckwheat, 1995

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