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Key Allergens

Celery-Mugwort-Spice Syndrome is essentially a sub-category of Pollen Food Allergy Syndrome. The body mistakes the shape of a protein that it is already sensitive to (a plant pollen) to a similarly shaped protein in certain fruits, vegetables, spices, herbs, and nuts.

As a less commonly seen type of Pollen Food Allergy it is referred to by multiple names.

  • Celery Carrot Mugwort Syndrome
  • Mugwort Mustard Allergy Syndrome
  • Mugwort Spice Syndrome
  • Celery Mugwort Birch Spice Syndrome
  • Mugwort Fennel Syndrome
  • Mugwort Peach Syndrome
  • Mugwort Chamomile Syndrome

  • In Celery-Mugwort-Spice Syndrome the sensitising pollen is from the mugwort plant and allergic reactions are to foods that contain proteins which are similarly shaped.

    In Pollen Food Allergy Syndrome the most common sensitising pollen is Bet v 1, which is an allergen from birch tree pollen. It is also sometimes referred to as a PR-10 protein (where PR means pathogenesis related). In Celery-Mugwort-Spice Syndrome the sensitising allergen is a profilin protein called Art v 4, sometimes also called Bet v 2 proteins.

    Symptoms and Treatment

    The symptoms associated with this syndrome are often referred to as OAS (Oral Allergy Syndrome) as it mostly affects people who already suffer from pollen allergies and seasonal rhinitis, but also includes a lot of oral symptoms like an itchy mouth, lips, tongue and throat.

    You are unlikely to have a severe allergic reaction from eating foods associated with this syndrome and they should go away with anti-histamines. The protein which causes the reaction is easily denatured with cooking, freezing or processing, there is evidence that peeling of certain fruits can also reduce the symptoms.

    Cross Reactivity

    Other plants containing profilin inhalant allergens are ragweed, wormwood, birch, sunflower, olive, plantain, poplar and oak.

    Profilins are also found as food allergens in kiwi, celery, peanut, chilli, watermelon, orange, hazelnut, melon, carrot, strawberry, soya, walnut, lychee, lupin, apple, cherry, almond, peach, pear, mustard, tomato and aubergine.

    The foods most commonly linked to Celery Mugwort Spice Syndrome are peach, melon, celery, carrots, camomile, fennel and other spices from the Apiaceae family which include coriander, caraway seed, celery, chervil, cumin, dill, aniseed and parsley.

    You can download a Celery-Mugwort-Spice Syndrome Factsheet from the Allergy Resources Ko-fi Shop for just $0.50 (£0.40 or €0.45). This has up to date information on which foods contain linked allergens and what to avoid if you think you have Celery-Mugwort-Spice Syndrome.



    Allergy UK - Information and Advice

    AAAAI - Oral Allergy Syndrome

    Anaphylaxis Campaign

    Allergen Encyclopedia - Mugwort

    Dermnet NZ - Pollen Food Allergy Syndrome

    Patient UK - Oral Allergy Syndrome

    Articles and Journals

    The use of inhibition assay in Api g 7 suspected allergy in a female patient with anaphylaxis: A case report, 2024

    The Role of Defensins as Pollen and Food Allergens, 2023

    Clinical Relevance of Profilin Sensitization Concerning Oral Allergy Syndrome in Birch Pollen Sensitized Patients, 2022

    Pollen-food allergy syndrome and component sensitization in adolescents: A Japanese population-based study, 2021

    Pollen-related food allergy in children with seasonal allergic rhinitis, 2021

    Heterogeneity of Pollen Food Allergy Syndrome in Seven Southern European Countries: the @IT.2020 Multicenter Study, 2021

    Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome, 2020

    Insights into pediatric pollen food allergy syndrome, 2020

    Food cross-reactivity in patients with pollen allergies, 2020

    Pollen-food allergy syndrome in children, 2020

    Update on pollen-food allergy syndrome, 2020

    Cross-reactivity between aeroallergens and food allergens, 2015

    Mugwort-fennel-allergy-syndrome associated with sensitization to an allergen homologous to Api g 5, 2013

    Oral Allergy Syndrome, 2010

    Curry spice allergy associated with pollen-food allergy syndrome and latex fruit-syndrome, 2009

    Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.

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