COCKROACH ALLERGY
Key Allergens
There are lots of families of cockroaches, the ones that are flagged by the World Health Organization (WHO) are the German cockroach which are in the
Ectobiidae family of insects and the American cockroach which is in the
Blattidae family of animals.
The main sources of cockroach allergens are cockroach saliva, faeces, eggs and shed skins.
Between them they have 24 allergens associated with them, the most well known being tropomyosin, an allergen found in fish, molluscs, crustaceans, dust mites and other insects and
chitinase proteins which are found in both insects and some plants. They also have lipocalin allergens, which are proteins more commonly associated with furry animal allergies, like cats, dogs and horses.
Enolase proteins were added to the WHO Allergen Nomenclature list of allergens for cockroaches in 2022. These are common inhalant proteins found in other animals and some plants.
As all the allergens associated with cockroaches are inhalant, the symptoms of an allergy to cockroaches would most likley be sneezing, wheezing, irritation of the nose, mouth and throat and in some cases worsening of asthma symptoms. The best approach to reduce symptoms of allergy to cockroaches is to attempt to eradicate them from your living spaces.
Associated Syndromes
Allergy to cockroachs is strongly associated with allergic rhinitis as well as asthma, rhinoconjunctivitis and atopic dermatitis.
Some species of cockroachs contain chitinase, which is a protein often linked to
Latex Allergy.
Cross Reactivity
Tropomyosin is both a food allergen and an airway allergen. In cockroaches the protein is an airway allergen. Other animals which contain this allergen include mosquito, storage mites, termites, dustmites and silverfish.
Tropomyosin as a food allergen is found in crab, shrimp, oysters, abalone, snails, lobsters, prawns, tilapia, catfish, crab, Atlantic salmon and squid.
Cockroaches also contain chitinase proteins which can cause an inhalant reaction. Foods containing chitinase include corn, avocado, banana, pomegranate, mango, coffee and chestnuts.
Enolase proteins are also found in fungus and moulds, cod, salmon, tuna, catfish, chicken and also in plants, latex, wormwood, grasses and ragweed.
Resources
Websites
DermNetNZ - Aeroallergens and the skin
Allergen Encyclopedia - American Cockroach
Allergen Encyclopedia - German Cockroach
Science Direct - Cockroach
Asthma and Allergy Foundation of America - Cockroaches
Articles and Journals
Hexamerin and allergen are required for female reproduction in the American cockroach, Periplaneta americana, 2024
Vitellin/Vitellogenin Is an Important Allergen in German Cockroach, 2024
Extraction, Purification, and Development of Sublingual Film (SLIT Films) Comprising Cockroach Allergen for Treatment of Allergy, 2023
Analysis of common allergens affecting patients with allergic rhinitis , 2023
Reported Cases and Diagnostics of Occupational Insect Allergy: A Systematic Review, 2023
Sensitization to house dust mite and cockroach may mediate the racial difference in shellfish allergy, 2022
Part II: Insect allergies—Inhalation and ingestion, 2022
IgE and T Cell Reactivity to a Comprehensive Panel of Cockroach Allergens in Relation to Disease, 2021
Respiratory sensitization to insect allergens: Species, components and clinical symptoms, 2021
Cockroach allergens: Coping with challenging complexity, 2019
Cockroach allergens and asthma in Brazil: Identification of tropomyosin as a major allergen with potential cross-reactivity with mite and shrimp allergens, 1999
The Role of Cockroach Allergy and Exposure to Cockroach Allergen in Causing Morbidity among Inner-City Children with Asthma, 1997
Let me know if you found any of these interesting or useful.
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