Key Allergens

There are 3 allergens associated with coffee allergy. Cof a 1 is a chitinase protein. Chitinase proteins are usually associated with Latex Food Syndrome, but in this case the allergen is an inhalant allergen and not a food allergen, so does not need to be avoided if suffering from this syndrome.

Cof a 2 and Cof a 3 are both metallothionein proteins. Again these are inhalant allergens and not food allergens and they are used in the plant to bind metals such as zinc.

Food Intolerances

Food is low in FODMAP Food is low in salicylates

Coffee is a low FODMAP food. FODMAP stands for Fermentable oligosaccharides, disaccharides, monosaccharides and polyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.

Coffee beans are low in salicylates (decaffinated coffee is also considered to be low). Salicylates have the potential to cause gastrointestinal food intolerance symptoms in people who are sensitive to salicylates.

You can read more about Food Intolerances on the dedicated Food Intolerance Page.

Associated Syndromes

Allergy to chitinase proteins has been linked to Latex Food Syndrome.

Coffee allergy has been linked to asthma, rhinoconjunctivitis and atopic dermatitis, especially in those who pick, pack or process coffee beans.

Cross Reactivity

Other foods containing chitinase proteins are chestnuts, banana, avocado, pomegranate and maize. Other plants containing chitinases which are considered to be inhalant allergens are cockroaches and dust mites.

Note this food list is not exhaustive, the most up to date information is on the Cross Reactivity Tool.



Allergen Encyclopedia - Coffee

Caffeine Allergy & Coffee Intolerance: What You Need to Know

Do I Have a Coffee Allergy?

Healthline - FODMAP foods

ATP Science - Salicylate Foods

Articles and Journals

A Comprehensive Review of the Nutritional Composition and Toxicological Profile of Date Seed Coffee (Phoenix dactylifera), 2024

Food Intolerances, Food Allergies and IBS: Lights and Shadows, 2024

Prevalence of Irritable Bowel Syndrome and Associated Factors among Patients with Migraine Attending Dubai Health Authority Clinics: A Cross Sectional Study, Dubai, 2024

Reported food-related symptoms and food allergen sensitization in a selected adult population in Hyderabad, India: A hospital-based survey, 2024

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations? 2023

Study of prevalence of skin prick test positivity for food allergens in chronic urticaria patients attending a tertiary care center in South India, 2022

Airborne allergic contact dermatitis caused by coffee beans in a coffee roaster, 2021

Food allergy in displaced people from Mosul City, 2021

Anaphylaxis caused by sodium caseinate contained in canned coffee, 2020

Food allergy test in chronic urticaria adult patients: A cross sectional study, 2019

Anaphylaxis to coffee from a specific geographic region, 2018

Identification of two metallothioneins as novel inhalative coffee allergens cof a 2 and cof a 3, 2015

Cof a 1: identification, expression and immunoreactivity of the first coffee allergen, 2012

Coffee Anyone? Are You at Risk of Allergy? 2012

Helminthic infection as a factor in new-onset coffee allergy in a father and daughter, 2008

Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.

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