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Gibberellin Proteins

This is a simplified description of gibberellin proteins – there are more resources available at the bottom of the page for further reading for those who are interested in knowing more.

What are gibberellin proteins?

Gibberellins are a lesser known allergen found in plants. They are a group of plant hormones found in seeds, young leaves, and roots. As such they are referred to in many studies as Gibberellin Regulated Proteins (GRP). The plant hormones are responsible for seed germination, shoot elongation, flowering and fruit development.

Gibberellin regulated proteins have been shown to maintain their shape after thermal processing and can be resistant to digestive enzymes. This makes them an important allergenic protein of note.

Which foods contain gibberellin regulated proteins?

The World Health Organization (WHO) recognises 6 foods as containing gibberellin regulated proteins known to cause allergic reactions after consumption of food.

Chilli, orange, cherry, apricot, peach and pomegranate all contain gibberellin proteins. Other studies have shown lotus roots, seeds and flowers also contain these proteins.

Which pollens contain gibberellin regulated proteins?

There are 3 pollen allergens associated with gibberellin regulated proteins including Japanese cedar, common cypress and common cedar trees.

What symptoms do they cause?

Allergy to foods containing gibberellins have a wide range of symptoms and severity including urticaria (hives or welts), angioedema (swelling under the skin), nausea, abdominal pain, vomiting or breathlessness and anaphylactic shock.

What is the importance of knowing whether a reaction is to gibberellins or other allergens?

Multiple allergies are becoming more common and this often leads people to impose a strict restrictive diet on themselves. This can lead to a poor diet lacking in essential nutrients and frustration over a lack of eating options. Knowing which foods are the most likely to be causing your reactions can bring more options back into your diet.

This is why food diaries continue to be an important tool in diagnosis of your allergies – noting the times reactions took place and what medications were taken are a necessary starting point for a proper diagnosis.

There is more information on food diaries HERE.


Brittanica - Gibberellin Proteins

Science Direct - Gibberellin

Articles and Journals

Impact of gibberellin-regulated protein allergy on quality of life, 2024

Increased allergic episodes induced by Japanese apricot following the Cupressaceae pollen season in adult patients mono-sensitized to Pru p 7, 2024

Allergy to Gibberellin-regulated proteins in an adolescent: A case of orange-induced anaphylaxis mediated by cofactors, 2024

Optimization of the diagnosis and characterization of gibberellin-regulated protein sensitization: an Italian cohort study, 2024

New arrivals in anaphylaxis to foods, 2023

Gibberellin-regulated proteins, 2023

Generalized allergic reaction in response to exercise due to strawberry gibberellin-regulated protein: a case report, 2022

Gibberellin-regulated protein sensitization in Japanese cedar (Cryptomeria japonica) pollen allergic Japanese cohorts, 2021

When the Frequencies of Sensitization and Elicitation of Allergic Reaction Do Not Correlate—The Case of Apple Gibberellin-Regulated Protein Tested in an Italian Population, 2021

Characterization of a 7 kDa pollen allergen belonging to the gibberellin-regulated protein family from three Cupressaceae species, 2020

Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome, 2020

Gibberellin-regulated protein allergy: Clinical features and cross-reactivity, 2019

Isolation of cypress gibberellin-regulated protein: Analysis of its structural features and IgE binding competition with homologous allergens, 2019

Identification of gibberellin-regulated protein as a new allergen in orange allergy, 2018

A new allergen family involved in pollen food-associated syndrome: Snakin/gibberellin-regulated proteins, 2018

High prevalence of sensitization to gibberellin-regulated protein (peamaclein) in fruit allergies with negative immunoglobulin E reactivity to Bet v 1 homologs and profilin: Clinical pattern, causative fruits and cofactor effect of gibberellin-regulated protein allergy, 2017

Panallergens and their impact on the allergic patient, 2010

Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.

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