ALLERGY RESOURCES

COMPREHENSIVE ALLERGY RESOURCES FOR EVERYONE - THE TOP 14 ALLERGENS AND BEYOND

COMPREHENSIVE ALLERGY RESOURCES FOR EVERYONE - THE TOP 14 ALLERGENS AND BEYOND

POMEGRANATE ALLERGY


Key Allergens

Pomegranates are in the Lythraceae family of plants. There are 3 allergens thought to cause allergic reactions in pomegranates.

Pun g 1 is a Lipid Transfer Protein (LTP). Most cases of pomegranate allergy are linked to this protein.

Pun g 7 is a gibberellin regulated protein, gibberellins are plant growth hormones.

Pun g 14 is a chitinase protein. This is a plant derived enzyme made by plants naturally to act as a defence against fungal attacks. Chitinase is a protein associated with an allergy to latex.

Food Intolerances

Food is low in FODMAP Food is low in salicylates

Pomegranate is a low FODMAP food. FODMAP stands for Fermentable oligosaccharides, disaccharides, monosaccharides and polyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.

Pomegranates are low in salicylates. Salicylates have the potential to cause gastrointestinal food intolerance symptoms in people who are sensitive to salicylates.

You can read more about Food Intolerances on the dedicated Food Intolerance Page.

Associated Syndromes

Pomegranate allergy is seen in conjunction with allergies to other foods presenting as Latex Food Syndrome, which is caused by the body confusing the proteins it encounters in food to that of latex proteins to which it is already sensitised.

LTPs are a group of proteins which can cause more serious allergic reactions in patients, you may suffer from LTP Syndrome if you suffer IgE type allergy symptoms to foods mentioned in the cross reactivity section below.

Cross Reactivity

Those with a sensitivity to chitinase may have linked allergies to foods which contain high levels of chitinase like chestnuts, banana, avocados, papaya, maize (corn), kiwi and tomatoes. Chitinase as an airway allergen is found in coffee, cockroaches and dust mite.

Common foods involved in LTP allergy include kiwi, strawberries, sunflower seeds, walnut, apple, mulberry, banana, pea, apricot, cherry, plum, almond, peach pomegranate, raspberry, tomato, grape, celery, peanut, asparagus, cabbage, broccoli, chestnut, lemon, tangerine, orange, hazelnut, lettuce, lentils, lupin, green bean, pear, mustard, wheat and maize.

Other plants containing gibberellin food allergens are chilli, bell pepper, orange, cherry, apricot and peach. Gibberellin airway allergens are cedar and cypress pollens.

These food lists are not exhaustive, the most up to date information is on the Cross Reactivity Tool.



Resources

Websites

Anaphylaxis Campaign - LTP Syndrome

ACAAI - Latex Allergy

Allergy information for: Pomegranate (Punica granatum )

FODMAPedia - Pomegranate

ATP Science - Salicylate Food List


Articles and Journals

Cross-reactive food and pollen allergens most commonly involved in oral allergy syndrome in adults with eosinophilic esophagitis, 2023

Analysis of Protein Sequence Identity, Binding Sites, and 3D Structures Identifies Eight Pollen Species and Ten Fruit Species with High Risk of Cross-Reactive Allergies, 2022

Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology, 2021

Insights into pediatric pollen food allergy syndrome, 2020

Chitinases as Food Allergens, 2019

A new allergen family involved in pollen food-associated syndrome: Snakin/gibberellin-regulated proteins, 2018

Pomegranate chitinase III: Identification of a new allergen and analysis of sensitization patterns to chitinases, 2018

Pomegranate Cultivars: Identification of the New IgE-Binding Protein Pommaclein and Analysis of Antioxidant Variability, 2017

Pomegranate (Punica granatum L.) expresses several nsLTP isoforms characterized by different immunoglobulin E-binding properties, 2014

Cross-reactivity syndromes in food allergy, 2013

Anaphylactic reactions to pomegranate: identification and characterization of eliciting IgE-reactive components, 2011

Detection of Some Safe Plant-Derived Foods for LTP-Allergic Patients, 2007

Class I chitinases as potential panallergens involved in the latex-fruit syndrome, 1999

Latex allergy: clinical features and cross-reactivity with fruits, 1994



Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.


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