Spinach is a food high in histamine
, so is not suitable for people following a low histamine diet.
Spinach is a low FODMAP food. FODMAP
stands for F
olyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.
Fresh spinach is a food high in salicylates
, frozen spinach has less present. Salicylates have the potential to cause gastrointestinal food intolerance symptoms in people who are sensitive to salicylates.
You can read more about Food Intolerances
on the dedicated Food Intolerance Page.
An allergy to spinach is associated with "Alternaria-Spinach syndrome". This is a rare syndrome and causes cross reactivity reactions in spinach and mushrooms (specifically a mould). This is more common in asthmatics as the proteins are involved in aero allergens.
Spinach has also been linked to Latex Food Syndrome
The Alt a 1 allergen in the Alternaria fungus is the cross reacting protein in Alternaria-Spinach Syndrome.
Other plants in the Amaranthaceae
family of plants include chard, beetroot, quinoa and amaranth.
The proteins involved in Latex Food Syndrome are hevein and chitinase.
Chitinase is found in avocado, banana, chestnuts, mango, corn (maize), kiwi, papaya, pomegranate, tamarind, cashews and tomatoes. Chitinase allergens can also affect the airways and can be found in coffee, cockroaches and dust mites.
Hevein proteins are found in rubber trees (as a contact allergen) and in turnip (as a food allergen).
These food lists are not exhaustive, the most up to date information is on the Cross Reactivity Tool.
Allergen Encyclopedia - Spinach
Science Direct - Amaranthaceae
High Histamine Foods
Healthline - FODMAP Foods
ATP Science - Salicylate Foods
Anaphylaxis Campaign - Vegetables
Articles and Journals
Pattern of Food Allergen Sensitivity Amongst Adult Allergic Rhinitis Patients: A Four Year Central Indian Study, 2023
Plant Food Dyes with Antioxidant Properties and Allergies—Friend or Enemy? 2023
Recent Advances in the Allergic Cross-Reactivity between Fungi and Foods, 2022
Alternaria as an Inducer of Allergic Sensitization, 2021
Cross-Reactive Aeroallergens: Which Need to Cross Our Mind in Food Allergy Diagnosis? 2018
Cross-reactivity between aeroallergens and food allergens, 2015
Urticaria and angioedema to rubisco allergen in spinach and tomato, 2012
Description of a Novel Panallergen of Cross-Reactivity between Moulds and Foods, 2009
Occupational asthma due to allergy to spinach powder in a pasta factory, 2005
A case of latex fruit syndrome caused by spinach and eggplant , 2004
Crossed spinach-latex allergy revealed by exercise-induced anaphylaxis, 1999
Oral allergy syndrome induced by spinach, 1997
Let me know if you found any of these interesting or useful.
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