Key Allergens

Grapes are in the Vitaceae family of plants. This family of plants includes multiple varieties of grapes.

The key allergen in grape is Vit v 1, this is a Lipid Transfer Protein (LTP). These proteins are resistant to heat and are found in many types of plants. Patients suffering from a more severe allergy to cooked fruit may be sensitised to this group of proteins.

Other allergens found in grapes include a profilin protein, a thaumatin protein and chintinase-like proteins.

A byproduct of winemaking is grapeseed oil, this is a vegetable oil made from the seeds of the grapes. All vegetable oils are highly processed, so are less likely to cause allergic reactions than the fresh or dried fruit.

When considering grape allergies you need to consider whether you are reacting to them in their fresh form, after they have been dried, to make sultanas and raisins or whether you have reacted to them in wine. Dried fruit and wine are both strongly linked with food intolerances, see section below.

Food Intolerances

Food is high in FODMAP Food is high in histamine Food is high in sulphites Food is high in lectins Food is high in salicylates

Grapes themselves are low in histamine, but red wine is high in histamine. The amount of histamine increases as fruit dries, so sultanas and raisins should also be avoided if you are following a low histamine diet.

Wines and wine vinegars are also high in sulphites. Fresh grapes are low in sulphites, but the amount increases as they dry, so raisins and sultanas are not suitable for people following a low sulphite diet. Sulphites are inorganic salts used in preservations and have the potential to cause symptoms of food intolerance to those sensitive to sulphites, this food intolerance is more common in asthmatics. An improvement in symptoms can be made with a change to a low sulphite diet.

Grapes are a low FODMAP food, but wine, especially fermented wines are high. FODMAP stands for Fermentable oligosaccharides, disaccharides, monosaccharides and polyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.

Fresh grapes, dried raisins, dried sultanas and wine are all foods high in salicylates. Salicylates have the potential to cause worsening of asthma, swelling, itching and hives as well as food intolerance symptoms in people who are sensitive to salicylates.

Grapes are one of the few fruits to contain a moderate amount of lectins, another cause of food intolerance. Cooking foods with lectins makes them more digestible and can reduce the symptoms of food intolerance.

You can read more about Food Intolerances on the dedicated Food Intolerance Page.

Associated Syndromes

You may be suffering from LTP Syndrome if you have reactions to various fruits, vegetables and nuts and your reactions continue to be severe after you have discarded the peel and have cooked the food.

Allergies to the protein chitinase can sometimes be linked to Latex Food Syndrome. Profilin proteins are also linked to this syndrome, but to a lesser degree as profilin proteins are more easily damaged by extremes of heat and processing.

Profilin protein allergies can also be linked to Celery Mugwort Spice Syndrome. The symptoms associated with this syndrome are often referred to as OAS (Oral Allergy Syndrome) as it mostly affects people who already suffer from pollen allergies and seasonal rhinitis, but also includes a lot of oral symptoms like an itchy mouth, lips, tongue and throat.

Cross Reactivity

Common foods involved in LTP allergy include kiwi, strawberries, sunflower seeds, walnut, apple, mulberry, banana, pea, apricot, cherry, plum, almond, peach pomegranate, raspberry, tomato, grape, celery, peanut, asparagus, cabbage, broccoli, chestnut, lemon, tangerine, orange, hazelnut, lettuce, lentils, lupin, green bean, pear, mustard, wheat and maize.

Other foods containing profilin include apples, cherry, corn, figs, kiwi, melon, mustard, plum, tomato and wheat.

Other foods containing thaumatin include apple, banana, pepper, chilli, celery, cherry, elderberry, elderflower, garlic, kiwi, peach and plantain.

Chitinase is a protein also found in avocado, banana, beetroot, cashew, chard, chestnut, coffee, corn, kiwi, mango, plantain, pomegranate, spinach and tamarind.

Note that none of these food lists are exhaustive, please visit the cross reactivity tools for the most up to date allergen records.



Science Direct - Lipid Transfer Proteins

Allergen Encyclopedia - Grapes

Lipid Transfer Proteins (LTP Syndrome)

Allergy to Fruit - Anaphylaxis Campaign

Histamine Foods

Histamine Intolerance Food List

Sulfite Food List

Healthline - FODMAP Foods

ATP Science - Salicylate Foods

Science Direct - Grapeseed Oils

Articles and Journals

Optimization of the diagnosis and characterization of gibberellin-regulated protein sensitization: An Italian cohort study, 2024

Evaluation of grape stems and grape stem extracts for sulfur dioxide replacement during grape wine production, 2023

Analysis of Protein Sequence Identity, Binding Sites, and 3D Structures Identifies Eight Pollen Species and Ten Fruit Species with High Risk of Cross-Reactive Allergies, 2022

Dietary Lectins: Gastrointestinal and Immune Effects, 2020

Lipid Transfer Protein allergy in the United Kingdom: Characterization and comparison with a matched Italian cohort, 2019

A case study of apple seed and grape allergy with sensitisation to nonspecific lipid transfer protein, 2016

Assessment of sensitization to grape and wine allergens as possible causes of adverse reactions to wine: a pilot study, 2015

A child with anaphylaxis to grapes without reaction to grape seed oil, 2009

Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndrome, 2007

Simultaneous Allergy to Vine Pollen and Grape, 2006

Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin, 2003

Allergy to grape: A case report, 2001

Exercise-induced anaphylaxis to grape, 2001

Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.

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