Pineapple is in the Bromeliaceae
family of plants. Plants in this family are almost always found in South America.
Ana c 1 is a profilin
protein, this is a panallergen known to sometimes cause allergy reactions in multiple foods containing similar proteins.
Ana c 2 is called bromelain. This has been known to cause IgE mediated allergies and symptoms most often related to the respiratory system. This biochemical is commonly extracted from pineapple and used in cosmetics and food production where it is frequently used as a meat tenderiser (which is why your lips may tingle when eating pineapple).
is a papain, which is the active constituent in latex-related fruits, this is a protein which can cause cross reactivity with latex.
Pineapple is a low FODMAP food. FODMAP
stands for F
olyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.
Fresh pineapple is a food high in salicylates (but pineapple juice alone can be low). Salicylates
have the potential to cause worsening of asthma, swelling, itching and hives as well as food intolerance symptoms in people who are sensitive to salicylates.
You can read more about Food Intolerances
on the dedicated Food Intolerance Page.
If you suffer from pineapple allergy and other foods mentioned in the cross reactivity section below you may suffer from Latex Food Syndrome.
Allergy to pineapple is sometimes linked to Celery-Mugwort-Spice Syndrome
as the sensitising allergen is a profilin protein called Art v 4, these proteins are also sometimes also called Bet v 2 proteins.
If sensitised to pineapple you may also be allergic to banana, papaya, avocado, chestnut, corn, kiwi, pomegranate and latex.
Other foods containing plant profilin proteins include pineapple, kiwi, celery, peanut, chilli, watermelon, muskmelon, hazelnut, orange, carrot, strawberry, soya beans, barley, walnut, lychee, lupin, apple, banana, dates, cherry, almond, peach, pear, mustard, tomato, aubergine and wheat.
Note that these food lists are not exhaustive. The most up to date information is on the Cross Reactivity Tool.
Allergen Encyclopedia - Pineapple
Science Direct - Papain
Allergy information for: Pineapple (Ananas comosus )
Allergy HQ - Pineapple
Healthline - Pineapple
FODMAPedia - Pineapple
ATP Science - Salicylate Foods
Articles and Journals
Efficacy and safety of bromelain: A systematic review and meta-analysis, 2023
Analysis of Protein Sequence Identity, Binding Sites, and 3D Structures Identifies Eight Pollen Species and Ten Fruit Species with High Risk of Cross-Reactive Allergies, 2022
The many flavors of pineapple reactions, 2019
Misleading Allergens in the Diagnosis of Latex Allergy: Profilin and Cross-Reactive Carbohydrate Determinants, 2018
Prevalence of oral allergy syndrome in children with allergic diseases, 2017
IgE reactivity to profilin in pollen-sensitized subjects with adverse reactions to banana and pineapple, 2002
Allergy to latex and papain, 1995
Systemic allergic reaction and diarrhoea after pineapple ingestion, 1993
Asthma caused by bromelain: an occupational allergy, 1988
Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure, 1979
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