Key Allergens

Pineapple is in the Bromeliaceae family of plants. Plants in this family are almost always found in South America.

Ana c 1 is a profilin protein, this is a panallergen known to sometimes cause allergy reactions in multiple foods containing similar proteins.

Ana c 2 is called bromelain. This has been known to cause IgE mediated allergies and symptoms most often related to the respiratory system. This biochemical is commonly extracted from pineapple and used in cosmetics and food production where it is frequently used as a meat tenderiser (which is why your lips may tingle when eating pineapple).

Bromelain is a papain, which is the active constituent in latex-related fruits, this is a protein which can cause cross reactivity with latex.

Food Intolerances

Food is low in FODMAP Food is high in salicylates

Pineapple is a low FODMAP food. FODMAP stands for Fermentable oligosaccharides, disaccharides, monosaccharides and polyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.

Fresh pineapple is a food high in salicylates (but pineapple juice alone can be low). Salicylates have the potential to cause worsening of asthma, swelling, itching and hives as well as food intolerance symptoms in people who are sensitive to salicylates.

You can read more about Food Intolerances on the dedicated Food Intolerance Page.

Associated Syndromes

If you suffer from pineapple allergy and other foods mentioned in the cross reactivity section below you may suffer from Latex Food Syndrome.

Allergy to pineapple is sometimes linked to Celery-Mugwort-Spice Syndrome as the sensitising allergen is a profilin protein called Art v 4, these proteins are also sometimes also called Bet v 2 proteins.

Cross Reactivity

If sensitised to pineapple you may also be allergic to banana, papaya, avocado, chestnut, corn, kiwi, pomegranate and latex.

Other foods containing plant profilin proteins include pineapple, kiwi, celery, peanut, chilli, watermelon, muskmelon, hazelnut, orange, carrot, strawberry, soya beans, barley, walnut, lychee, lupin, apple, banana, dates, cherry, almond, peach, pear, mustard, tomato, aubergine and wheat.

Note that these food lists are not exhaustive. The most up to date information is on the Cross Reactivity Tool.



Allergen Encyclopedia - Pineapple

Science Direct - Papain

Allergy information for: Pineapple (Ananas comosus )

Allergy HQ - Pineapple

Healthline - Pineapple

FODMAPedia - Pineapple

ATP Science - Salicylate Foods

Articles and Journals

IgE food sensitization and self-reported symptoms in a school-aged cohort from Honduras, 2024

Efficacy and safety of bromelain: A systematic review and meta-analysis, 2023

Analysis of Protein Sequence Identity, Binding Sites, and 3D Structures Identifies Eight Pollen Species and Ten Fruit Species with High Risk of Cross-Reactive Allergies, 2022

The many flavors of pineapple reactions, 2019

Misleading Allergens in the Diagnosis of Latex Allergy: Profilin and Cross-Reactive Carbohydrate Determinants, 2018

Prevalence of oral allergy syndrome in children with allergic diseases, 2017

IgE reactivity to profilin in pollen-sensitized subjects with adverse reactions to banana and pineapple, 2002

Allergy to latex and papain, 1995

Systemic allergic reaction and diarrhoea after pineapple ingestion, 1993

Asthma caused by bromelain: an occupational allergy, 1988

Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure, 1979

Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook or Twitter - links at the bottom of the page.

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