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Key Allergens

Bromelain is an enzyme, which is found in pineapples and is often extracted and used in cosmetics, meat rubs and marinades. More recently it is being sold as a health supplement.

The enzyme is found in all parts of the pineapple, but in higher concentrations in the stems. The enzyme is a protease, which means it breaks down another substance, in this instance it breaks down some of the bonds in meat, making it more tender to eat when cooked.

When eating fresh pineapple it is the bromelain enzyme which gives you the tingly/itchy sensation in your mouth and throat. This can be mistaken for an allergic reaction. You can read more on the Pineapple Page.

Bromelain is actually a defined allergen with the World Health Organization (WHO) - Ana c 2, so is well documented as causing allergic reactions.

The enzyme is a papain, which is the active constituent in latex-related fruits, this is the protein which can cause cross reactivity with latex.

Bromelain is an allergen in itself, but the fresh pineapple from which it is extracted also contain profilin proteins. These are more easily damaged with heat and processing than other allergens, so are less likely to be the cause of an allergic reaction to bromelain.

Food Intolerances

Food is high in salicylates Food is low in FODMAP

Bromelain, like pineapple, is a low FODMAP food. FODMAP stands for Fermentable oligosaccharides, disaccharides, monosaccharides and polyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.

Like pineapple, bromelain is thought to also be high in salicylates. Salicylates have the potential to cause worsening of asthma, swelling, itching and hives as well as food intolerance symptoms in people who are sensitive to salicylates.

You can read more about Food Intolerances on the dedicated Food Intolerance Page.

Associated Syndromes

Bromelain is linked to a worsening of asthma symptoms and irritation of dermatitis.

It is also linked to Latex Food Syndrome. This is where a person who has a latex allergy will get similar symptoms if they eat food with similarly shaped proteins.

Allergy to pineapple and bromelain is sometimes linked to Celery-Mugwort-Spice Syndrome as the sensitising allergen is a profilin protein. This can cause allergic reactions in people eating lots of seemingly unrelated foods.

Cross Reactivity

Foods linked to Latex Food Syndrome are ones which contain the allergens hevein, chitinase and papains. Papain is most commonly linked with papaya.

Those with a sensitivity to chitinase may have linked allergies to foods which contain high levels of chitinase like avocado, banana, chestnuts, mango, corn (maize), kiwi, papaya, pomegranate, tamarind, cashews, beetroot, chard, spinach and tomatoes. Chitinase allergens can also affect the airways and can be found in coffee, cockroaches and dust mites.

Hevein proteins are found in rubber trees (as a contact allergen) and in turnip (as a food allergen).

Profilin proteins are found in celery, peanut, soyabeans, walnut, lupin, almonds, mustard, hazelnut, kiwi, pineapple, chilli, melon, orange, strawberry, lychee, apple, banana, aubergine (eggplant), peach, pear, tomato, dates, cherry and carrot.

These food lists are not exhaustive, you can see the most up to date food lists on the Cross Reactivity Tool.



Web MD - Bromelain

Allergen Encyclopedia - Pineapple

Science Direct - Bromelain

Science Direct - Papain

Articles and Journals

Plant and Arthropod IgE-Binding Papain-like Cysteine Proteases: Multiple Contributions to Allergenicity, 2024

Efficacy and safety of bromelain: A systematic review and meta-analysis, 2023

Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective, 2021

Occupational allergies to bromelain, 2007

Bromelain, 2006

Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy, 2004

Asthma caused by bromelain: an occupational allergy, 1998

Let me know if you found any of these interesting or useful. If you spot an article or research that you think is interesting you can message me or tag me on Facebook, Instagram or Twitter - links at the bottom of the page.

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