Pears are in the Rosaceae
family of plants which includes apples, plums, cherries, almonds, raspberries and strawberries.
Most people suffering from this allergy are thought to be sensitised to the protein Pyr c 1, which is similar in shape to Bet v 1
which is a protein found in birch pollen. This can cause cross reactions with other fruit.
Pyr c 3 is a Lipid Transfer Protein
(LTP), more severe reactions to eating pears are thought to be caused by these proteins.
Pyr c 4 is a profilin protein
, these proteins are considered to be panallergens and can cause issues over many groups of foods.
Pyr c 5 is an isoflavone reductase related protein.
Pear is a high FODMAP food. FODMAP
stands for F
olyols. Foods high in FODMAPs can cause symptoms of food intolerance, affecting the gastro intestinal system and this can be mistaken for a true IgE food allergy.
Pears contain a moderate amount of salicylates
. Salicylates have the potential to cause worsening of asthma, swelling, itching and hives as well as food intolerance symptoms in people who are sensitive to salicylates.
You can read more about Food Intolerances
on the dedicated Food Intolerance Page.
You may have Pollen-Food Allergy Syndrome
if you suffer from pear allergy with oral allergy symptoms to 3 or more of the foods mentioned in cross reactivity section.
Allergy to pear is sometimes linked to Celery-Mugwort-Spice Syndrome
as the sensitising allergen is a profilin protein called Art v 4, these proteins are also sometimes also called Bet v 2 proteins.
There is a link between pear and Latex Food Syndrome
. The plant involved in latex allergy Hevea brasiliensis
, the rubber tree plant, has an allergen called Hev b 8 which is a profilin protein. Those very sensitised to latex may have a contact allergic reaction from other foods or plants containing profilin proteins, there is less evidence of this than sensitisation to other latex linked proteins like hevein and chitinases.
You may be suffering from LTP Syndrome
if you suffer allergic reactions from eating 3 or more foods mentioned in the cross reactivity section below.
If sensitised to alder tree pollen you may have Pollen Food Allergy Syndrome and may also react to apple, peach, pear, parsley, celery, almonds and hazelnuts.
If sensitised to birch tree pollen you may have Pollen Food Allergy Syndrome and may also react to kiwi, pear, peach, plum, nectarine, apricots, apple, tomato, celery, carrot, potato, parsnip, pepper, dill, cumin, peas, coriander, fennel, hazelnut, walnut, almonds, peanuts, lentils and beans.
Common foods involved in LTP allergy include kiwi, strawberries, sunflower seeds, walnut, apple, mulberry, banana, pea, apricot, cherry, plum, almond, peach pomegranate, raspberry, tomato, grape, celery, peanut, asparagus, cabbage, broccoli, chestnut, lemon, tangerine, orange, hazelnut, lettuce, lentils, lupin, green bean, pear, mustard, wheat and maize.
Other foods containing plant profilins are carrot, kiwi, pineapple, celery, peanut, chilli, watermelon, orange, hazelnut, melon, strawberry, soya, barley, walnut, lychee, lupin, apple, banana, date, cherry, almond, peach, pear, mustard, tomato, aubergine and wheat.
Only carrots and pears contain isoflavone reductase-like proteins.
Allergen Encyclopedia - Pear
DermNet NZ - Pollen Food Allergy Syndrome
British Dietetic Association - PFAS vs LTP Syndrome
OAS – When Raw Fruit is Forbidden
Allergy information for: Pear (Pyrus communis)
Allergy to Fruit - Anaphylaxis Campaign
Allergy UK - Oral Allergy Syndrome
Patient UK - Oral Allergy Syndrome
Healthline - FODMAP Foods
ATP Science - Salicylate Foods
Articles and Journals
Pollen Food Allergy Syndrome in Japanese Children and Adolescents: Risk Factors and Pollen Sensitisation, 2023
Analysis of Protein Sequence Identity, Binding Sites, and 3D Structures Identifies Eight Pollen Species and Ten Fruit Species with High Risk of Cross-Reactive Allergies, 2022
Allergen Tests of Fruit Sensitization Involving Children with Allergic Diseases, 2022
Rosaceae food allergy: a review, 2022
Birch Pollen Related Pear Allergy: A Single-Blind Oral Challenge trial with 2 Pear Cultivars, 2021
The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area, 2021
Pollen-food allergy syndrome and component sensitization in adolescents: A Japanese population-based study, 2021
Pollen-related food allergy in children with seasonal allergic rhinitis, 2021
Pollen-food allergy syndrome in children, 2020
Pru p 3 oral immunotherapy efficacy, induced immunological changes and quality of life improvement in patients with LTP syndrome, 2020
Pyr c 1, the major allergen from pear (Pyrus communis), is a new member of the Bet v 1 allergen family, 2001
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